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Desmoplakin
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Belongs to the plakin or cytolinker family. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 13|13 A3.3 |
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Cellular Component:
basolateral plasma membrane; cell junction; cell-cell junction; cornified envelope; cytoplasm; cytoskeleton; desmosome; fascia adherens; intercalated disc; membrane; plasma membrane
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Molecular Function:
cell adhesion molecule binding; protein binding; protein kinase C binding; scaffold protein binding; structural molecule activity
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Biological Process:
adherens junction organization; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell-cell adhesion; desmosome organization; intermediate filament cytoskeleton organization; intermediate filament organization; keratinocyte differentiation; peptide cross-linking; protein localization to adherens junction; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; skin development; ventricular compact myocardium morphogenesis; wound healing
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Reference #:
E9Q557
(UniProtKB)
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Alt. Names/Synonyms: 2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; Desmoplakin; desmoplakin I/II; desmosomal cytoskeletal connector molecule; DESP; DP; Dsp; rul
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Gene Symbols: Dsp
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Molecular weight:
332,912 Da
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Basal Isoelectric point:
6.43
Predict pI for various phosphorylation states
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