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VIRMA
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA). Belongs to the vir family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing; Spliceosome |
| Chromosomal Location of mouse Ortholog: 4|4 A1 |
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Cellular Component:
cytoplasm; cytosol; nuclear body; nuclear speck; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
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Biological Process:
mRNA alternative polyadenylation; mRNA methylation; mRNA processing; multicellular organism development; RNA splicing
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Reference #:
A2AIV2
(UniProtKB)
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Alt. Names/Synonyms: 1110037F02Rik; 4930422M05Rik; Kiaa1429; mKIAA1429; Protein virilizer homolog; VIR; vir like m6A methyltransferase associated; Virma
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Gene Symbols: Virma
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Molecular weight:
201,439 Da
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Basal Isoelectric point:
4.84
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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