VIRMA Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA). Belongs to the vir family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Spliceosome
Chromosomal Location of Human Ortholog: 4|4 A1
Cellular Component:  cytoplasm; cytosol; nuclear body; nuclear speck; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
Biological Process:  mRNA alternative polyadenylation; mRNA methylation; mRNA processing; multicellular organism development; RNA splicing
Reference #:  A2AIV2 (UniProtKB)
Alt. Names/Synonyms: 1110037F02Rik; 4930422M05Rik; Kiaa1429; mKIAA1429; Protein virilizer homolog; VIR; vir like m6A methyltransferase associated; Virma
Gene Symbols: Virma
Molecular weight: 201,439 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VIRMA

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene