QARS Glutamine--tRNA ligase. Plays a critical role in brain development. Belongs to the class-I aminoacyl-tRNA synthetase family. Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC; Ligase; Mitochondrial; Translation; Translation regulation
Chromosomal Location of mouse Ortholog: 9|9 F2
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; protein-containing complex
Molecular Function:  aminoacyl-tRNA ligase activity; ATP binding; glutamine-tRNA ligase activity; ligase activity; nucleotide binding; protein kinase binding; protein kinase inhibitor activity; RNA binding
Biological Process:  brain development; glutaminyl-tRNA aminoacylation; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of DNA-templated transcription; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; translation; tRNA aminoacylation; tRNA aminoacylation for protein translation
Reference #:  Q8BML9 (UniProtKB)
Alt. Names/Synonyms: 1110018N24Rik; 1200016L19Rik; C80286; GLNRS; Glutamine--tRNA ligase; glutamine-tRNA ligase; glutaminyl-tRNA synthetase; MGC105238; Qars; Qars1; SYQ
Gene Symbols: Qars
Molecular weight: 87,604 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein