HBXAP Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 7|7 E1
Cellular Component:  nucleoplasm; nucleus; RSF complex
Molecular Function:  histone binding; histone octamer slider activity
Biological Process:  chromatin remodeling; DNA-templated transcription initiation; negative regulation of DNA binding; negative regulation of DNA-templated transcription; nucleosome assembly; positive regulation of DNA-templated transcription; positive regulation of viral transcription; regulation of DNA-templated transcription
Reference #:  E9PWW9 (UniProtKB)
Alt. Names/Synonyms: 4832420A03Rik; C030033M12Rik; Gm164; Hbx; Hbxap; hepatitis B virus x associated protein; MGC90806; p32; p325; remodeling and spacing factor 1; Rsf1; XAP8
Gene Symbols: Rsf1
Molecular weight: 161,750 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein