MDM2 a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 via Akt-mediated MDM2 phosphorylation. Phosphorylation of MDM2 increases its interaction with p300, providing a platform to allow the assembly of the protein complex necessary for MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. Facilitates the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Eight alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Inhibitor; Ligase; Nucleolus; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 10 D2|10 66.32 cM
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; synapse
Molecular Function:  5S rRNA binding; disordered domain specific binding; enzyme binding; identical protein binding; ligase activity; metal ion binding; NEDD8 ligase activity; p53 binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein N-terminus binding; receptor serine/threonine kinase binding; ribonucleoprotein complex binding; scaffold protein binding; SUMO transferase activity; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  amyloid fibril formation; atrial septum development; atrioventricular valve morphogenesis; blood vessel development; blood vessel remodeling; cardiac septum morphogenesis; cellular response to actinomycin D; cellular response to gamma radiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endocardial cushion morphogenesis; establishment of protein localization; heart development; heart valve development; negative regulation of apoptotic process; negative regulation of cell cycle arrest; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of neuron projection development; negative regulation of protein processing; negative regulation of signal transduction by p53 class mediator; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; peptidyl-lysine modification; positive regulation of cell cycle; positive regulation of gene expression; positive regulation of mitotic cell cycle; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein export from nucleus; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular smooth muscle cell proliferation; protein autoubiquitination; protein destabilization; protein localization to nucleus; protein ubiquitination; protein-containing complex assembly; proteolysis involved in cellular protein catabolic process; regulation of gene expression; regulation of heart rate; regulation of protein catabolic process; response to water-immersion restraint stress; traversing start control point of mitotic cell cycle; ubiquitin-dependent protein catabolic process; ventricular septum development
Reference #:  P23804 (UniProtKB)
Alt. Names/Synonyms: 1700007J15Rik; AA415488; Double minute 2 protein; E3 ubiquitin-protein ligase Mdm2; Mdm-2; Mdm2; Oncoprotein Mdm2; OTTMUSP00000022916; p53-binding protein Mdm2; transformed mouse 3T3 cell double minute 2
Gene Symbols: Mdm2
Molecular weight: 54,558 Da
Basal Isoelectric point: 4.65  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G2/M DNA Damage Checkpoint  |  PI3K/Akt Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene