|
NARFL
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. Belongs to the NARF family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 17|17 A3.3 |
|
Cellular Component:
CIA complex
|
|
Molecular Function:
4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; metal ion binding
|
|
Biological Process:
hematopoietic progenitor cell differentiation; iron-sulfur cluster assembly; oxygen homeostasis; regulation of gene expression; response to hypoxia
|
|
Reference #:
Q7TMW6
(UniProtKB)
|
|
Alt. Names/Synonyms: 9030612I22Rik; AI504405; CIAO3; Cytosolic Fe-S cluster assembly factor NARFL; Cytosolic iron-sulfur assembly component 3; IOP1; Iron-only hydrogenase-like protein 1; Narfl; nuclear prelamin A recognition factor-like; Nuclear prelamin A recognition factor-like protein; PRN
|
|
Gene Symbols: Narfl
|
|
Molecular weight:
53,108 Da
|
|
Basal Isoelectric point:
6.05
Predict pI for various phosphorylation states
|
