NARFL Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. Belongs to the NARF family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17|17 A3.3
Cellular Component:  CIA complex
Molecular Function:  4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; metal ion binding
Biological Process:  hematopoietic progenitor cell differentiation; iron-sulfur cluster assembly; oxygen homeostasis; regulation of gene expression; response to hypoxia
Reference #:  Q7TMW6 (UniProtKB)
Alt. Names/Synonyms: 9030612I22Rik; AI504405; CIAO3; Cytosolic Fe-S cluster assembly factor NARFL; Cytosolic iron-sulfur assembly component 3; IOP1; Iron-only hydrogenase-like protein 1; Narfl; nuclear prelamin A recognition factor-like; Nuclear prelamin A recognition factor-like protein; PRN
Gene Symbols: Narfl
Molecular weight: 53,108 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene