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NUP153
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). Belongs to the NUP153 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear export; Nucleoporin |
| Chromosomal Location of mouse Ortholog: 13|13 A5 |
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Cellular Component:
annulate lamellae; cytosol; membrane; nuclear envelope; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore nuclear basket; nucleolus; nucleoplasm; nucleoplasmic side of nuclear pore; protein-containing complex
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Molecular Function:
chromatin binding; double-stranded DNA binding; identical protein binding; nuclear localization sequence binding; protein binding; protein-membrane adaptor activity; small GTPase binding; structural constituent of nuclear pore; zinc ion binding
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Biological Process:
negative regulation of RNA export from nucleus; nuclear pore complex assembly; nucleocytoplasmic transport; protein import into nucleus; RNA export from nucleus
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Reference #:
Q80WR0
(UniProtKB)
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Alt. Names/Synonyms: B130015D15Rik; C88147; nuclear pore complex protein Nup153; Nucleoporin 153; Nup153
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Gene Symbols: Nup153
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Molecular weight:
152,068 Da
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Basal Isoelectric point:
9.04
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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