ARL3
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium. Belongs to the small GTPase superfamily. Arf family. Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level). Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; Cytoskeletal; G protein, monomeric; G protein, monomeric, ARF |
Chromosomal Location of human Ortholog: 10q24.32 |
Cellular Component:
centrosome; cilium; cytoplasm; cytoplasmic microtubule; Golgi apparatus; Golgi membrane; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; photoreceptor connecting cilium; spindle microtubule
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Molecular Function:
GDP binding; GTP binding; GTPase activity; magnesium ion binding; microtubule binding; protein binding
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Biological Process:
cilium assembly; Golgi to plasma membrane transport; intraciliary transport; kidney development; mitotic cytokinesis; photoreceptor cell development; post-Golgi vesicle-mediated transport; protein localization to ciliary membrane; protein localization to cilium; protein transport; small GTPase mediated signal transduction; smoothened signaling pathway
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Disease: Joubert Syndrome 35; Retinitis Pigmentosa 83
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Reference #:
P36405
(UniProtKB)
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Alt. Names/Synonyms: ADP ribosylation factor like GTPase 3; ADP-ribosylation factor-like 3; ADP-ribosylation factor-like protein 3; ARF-like 3; ARFL3; ARL3; JBTS35; RP83
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Gene Symbols: ARL3
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Molecular weight:
20,456 Da
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Basal Isoelectric point:
6.74
Predict pI for various phosphorylation states
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