CCAR1 Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator; RNA splicing
Chromosomal Location of Human Ortholog: 10|10 B4
Cellular Component:  cytoplasm; nuclear envelope lumen; nucleus
Molecular Function:  nuclear receptor transcription coactivator activity; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity
Biological Process:  apoptotic process; cell cycle; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cell proliferation; regulation of transcription, DNA-templated
Reference #:  Q8CH18 (UniProtKB)
Alt. Names/Synonyms: 2610511G16Rik; 9430036H15Rik; CARP-1; Carp1; Ccar1; Cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator 1; Cell division cycle and apoptosis regulator protein 1; MGC90759
Gene Symbols: Ccar1
Molecular weight: 132,060 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA