CCAR1 Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells. Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator; RNA splicing
Chromosomal Location of mouse Ortholog: 10|10 B4
Cellular Component:  cytoplasm; nuclear envelope lumen; nucleus
Molecular Function:  nuclear receptor coactivator activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity
Biological Process:  apoptotic process; cell cycle; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cell population proliferation; regulation of DNA-templated transcription
Reference #:  Q8CH18 (UniProtKB)
Alt. Names/Synonyms: 2610511G16Rik; 9430036H15Rik; CARP-1; Carp1; Ccar1; Cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator 1; Cell division cycle and apoptosis regulator protein 1; MGC90759
Gene Symbols: Ccar1
Molecular weight: 132,060 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA