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L-Myc
a proto-oncogenic transcription factor. Targets include CCL6 chemokine gene. Plays a role in cell proliferation, apoptosis and in the development of human tumors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein; Transcription factor |
| Chromosomal Location of mouse Ortholog: 4 D2.2|4 57.36 cM |
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Cellular Component:
chromosome; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
regulation of DNA-templated transcription; regulation of inner ear auditory receptor cell differentiation; regulation of transcription by RNA polymerase II
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Reference #:
P10166
(UniProtKB)
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Alt. Names/Synonyms: AW536278; bHLHe3; bHLHe38; L-my; L-myc; L-myc-1 proto-oncogene protein; Lmyc; Lmyc-; Lmyc-1; Lmyc1; lung carcinoma myc related oncogene 1; MGC102165; Mycl; Mycl1; OTTMUSP00000009305; OTTMUSP00000009306; Protein L-Myc; Protein L-Myc-1; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian); v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived
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Gene Symbols: Mycl
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Molecular weight:
40,848 Da
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Basal Isoelectric point:
5.22
Predict pI for various phosphorylation states
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