MEAF6 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Belongs to the EAF6 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Unknown function
Chromosomal Location of Human Ortholog: 4|4 D2.2
Cellular Component:  chromosome; chromosome, centromeric region; histone acetyltransferase complex; kinetochore; MOZ/MORF histone acetyltransferase complex; NuA3a histone acetyltransferase complex; NuA3b histone acetyltransferase complex; NuA4 histone acetyltransferase complex; nucleolus; nucleus
Biological Process:  chromatin organization; histone acetylation; histone H2A acetylation; histone H3-K14 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation
Reference #:  Q2VPQ9 (UniProtKB)
Alt. Names/Synonyms: 2310005N01Rik; 2810036M01Rik; Chromatin modification-related protein MEAF6; EAF6; Esa1-associated factor 6 homolog; Meaf6; MYST/Esa1-associated factor 6; OTTMUSP00000009604; Protein EAF6 homolog
Gene Symbols: Meaf6
Molecular weight: 21,649 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene