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THEMIS
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Belongs to the themis family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation |
| Chromosomal Location of mouse Ortholog: 10|10 A4 |
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Cellular Component:
cell-cell junction; COP9 signalosome; cytoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
adaptive immune response; immune system process; multicellular organism development; negative T cell selection; positive T cell selection; T cell receptor signaling pathway
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Reference #:
Q8BGW0
(UniProtKB)
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Alt. Names/Synonyms: A430108D01; BB160712; E430004N04Rik; Gasp; Grb2-associating protein; Protein THEMIS; Protein thylex; signaling phosphoprotein specific for T cells; Spot; Themis; THMS1; thylex; thymocyte selection associated; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; thymus lymphocyte exclusively expressed; Tsepa
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Gene Symbols: Themis
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Molecular weight:
72,780 Da
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Basal Isoelectric point:
5.77
Predict pI for various phosphorylation states
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