THEMIS Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Belongs to the themis family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of mouse Ortholog: 10|10 A4
Cellular Component:  cell-cell junction; COP9 signalosome; cytoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  adaptive immune response; immune system process; multicellular organism development; negative T cell selection; positive T cell selection; T cell receptor signaling pathway
Reference #:  Q8BGW0 (UniProtKB)
Alt. Names/Synonyms: A430108D01; BB160712; E430004N04Rik; Gasp; Grb2-associating protein; Protein THEMIS; Protein thylex; signaling phosphoprotein specific for T cells; Spot; Themis; THMS1; thylex; thymocyte selection associated; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; thymus lymphocyte exclusively expressed; Tsepa
Gene Symbols: Themis
Molecular weight: 72,780 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene