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EME1
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Belongs to the EME1/MMS4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Deoxyribonuclease; EC 3.1.22.-; Nucleolus |
| Chromosomal Location of Human Ortholog: 11|11 D |
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Cellular Component:
Holliday junction resolvase complex; nuclear chromatin; nuclear heterochromatin; nucleus
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Molecular Function:
DNA binding; endonuclease activity; hydrolase activity; metal ion binding; nuclease activity; protein binding
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Biological Process:
cellular response to DNA damage stimulus; DNA recombination; DNA repair; double-strand break repair; intra-S DNA damage checkpoint; replication fork processing; resolution of meiotic recombination intermediates; response to intra-S DNA damage checkpoint signaling
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Reference #:
Q8BJW7
(UniProtKB)
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Alt. Names/Synonyms: 6820428D13; Crossover junction endonuclease EME1; Eme1; essential meiotic endonuclease 1 homolog 1; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic structure-specific endonuclease 1; MGC106543; OTTMUSP00000001959; RP23-290B5.3
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Gene Symbols: Eme1
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Molecular weight:
63,481 Da
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Basal Isoelectric point:
9.11
Predict pI for various phosphorylation states
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