EME1 Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Belongs to the EME1/MMS4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deoxyribonuclease; EC 3.1.22.-; Nucleolus
Chromosomal Location of mouse Ortholog: 11|11 D
Cellular Component:  chromatin; endodeoxyribonuclease complex; heterochromatin; Holliday junction resolvase complex; nuclear replication fork; nucleus
Molecular Function:  DNA binding; endonuclease activity; hydrolase activity; metal ion binding; nuclease activity; protein binding
Biological Process:  cellular response to DNA damage stimulus; DNA recombination; DNA repair; double-strand break repair; mitotic intra-S DNA damage checkpoint signaling; replication fork processing; resolution of meiotic recombination intermediates; response to intra-S DNA damage checkpoint signaling
Reference #:  Q8BJW7 (UniProtKB)
Alt. Names/Synonyms: 6820428D13; Crossover junction endonuclease EME1; Eme1; essential meiotic endonuclease 1 homolog 1; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic structure-specific endonuclease 1; MGC106543; OTTMUSP00000001959; RP23-290B5.3
Gene Symbols: Eme1
Molecular weight: 63,481 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene