DOK2 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. Belongs to the DOK family. Type A subfamily. Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14 D2|14 36.71 cM
Cellular Component: 
Molecular Function:  protein binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  negative regulation of MAPK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  O70469 (UniProtKB)
Alt. Names/Synonyms: Docking protein 2; Dok-R; Dok-related protein; Dok2; DokR; Downstream of tyrosine kinase 2; FRIP; IL-Four Receptor Interacting Protein; IL-four receptor-interacting protein; p56 dok-2; p56(dok-2)
Gene Symbols: Dok2
Molecular weight: 45,522 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DOK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene