DPYD
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Belongs to the dihydropyrimidine dehydrogenase family. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 1.3.1.2; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes |
Chromosomal Location of mouse Ortholog: 3|3 G1 |
Cellular Component:
cytoplasm; cytosol
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Molecular Function:
4 iron, 4 sulfur cluster binding; dihydropyrimidine dehydrogenase (NADP+) activity; FAD binding; identical protein binding; iron ion binding; iron-sulfur cluster binding; metal ion binding; NADP binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; protein homodimerization activity; uracil binding
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Biological Process:
circadian rhythm; CMP catabolic process; dCMP catabolic process; dTMP catabolic process; dUMP catabolic process; purine nucleobase catabolic process; pyrimidine nucleobase catabolic process; response to nutrient; response to organic cyclic compound; response to xenobiotic stimulus; thymidine catabolic process; thymine catabolic process; UMP catabolic process; uracil catabolic process; uracil metabolic process
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Reference #:
Q8CHR6
(UniProtKB)
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Alt. Names/Synonyms: AI315208; DHPDHase; dihydropyrimidine dehydrogenase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydropyrimidine dehydrogenase [NADP+]; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; Dpyd; E330028L06Rik; MGC37940; OTTMUSP00000031746
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Gene Symbols: Dpyd
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Molecular weight:
111,253 Da
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Basal Isoelectric point:
7.13
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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