DPYD Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Belongs to the dihydropyrimidine dehydrogenase family. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 1.3.1.2; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 3|3 G1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  4 iron, 4 sulfur cluster binding; catalytic activity; dihydropyrimidine dehydrogenase (NADP+) activity; dihydrouracil dehydrogenase (NAD+) activity; FAD binding; iron ion binding; iron-sulfur cluster binding; metal ion binding; NADP binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; protein homodimerization activity; uracil binding
Biological Process:  circadian rhythm; purine nucleobase catabolic process; pyrimidine nucleobase catabolic process; response to drug; response to nutrient; response to organic cyclic compound; thymidine catabolic process; thymine catabolic process; uracil catabolic process; uracil metabolic process
Reference #:  Q8CHR6 (UniProtKB)
Alt. Names/Synonyms: AI315208; DHPDHase; dihydropyrimidine dehydrogenase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydropyrimidine dehydrogenase [NADP+]; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; Dpyd; E330028L06Rik; MGC37940; OTTMUSP00000031746
Gene Symbols: Dpyd
Molecular weight: 111,253 Da
Basal Isoelectric point: 7.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DPYD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene