NRK
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: EC 2.7.11.1; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
Chromosomal Location of mouse Ortholog: X F1|X 61.15 cM |
Cellular Component:
|
Molecular Function:
ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
|
Biological Process:
negative regulation of cell population proliferation; parturition; phosphorylation; positive regulation of JNK cascade; protein phosphorylation; regulation of spongiotrophoblast cell proliferation
|
Reference #:
Q9R0G8
(UniProtKB)
|
Alt. Names/Synonyms: AA407323; AA409510; AI225895; AV168563; AW538185; Nck-interacting kinase-like embryo specific kinase; NESK; Nik related kinase; NIK-like embryo-specific kinase; Nik-related protein kinase; Nrk; ZC4
|
Gene Symbols: Nrk
|
Molecular weight:
163,647 Da
|
Basal Isoelectric point:
6.05
Predict pI for various phosphorylation states
|