NRK May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of mouse Ortholog: X F1|X 61.15 cM
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton reorganization; activation of JNKK activity; activation of protein kinase activity; MAPK cascade; negative regulation of cell proliferation; neuron projection morphogenesis; parturition; phosphorylation; protein phosphorylation; regulation of spongiotrophoblast cell proliferation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q9R0G8 (UniProtKB)
Alt. Names/Synonyms: AA407323; AA409510; AI225895; AV168563; AW538185; Nck-interacting kinase-like embryo specific kinase; NESK; Nik related kinase; NIK-like embryo-specific kinase; Nik-related protein kinase; Nrk; ZC4
Gene Symbols: Nrk
Molecular weight: 163,647 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene