MEKK6 Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of Human Ortholog: 4|4 D2.3
Cellular Component: 
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of MAPKK activity; phosphorylation; protein phosphorylation
Reference #:  Q9WTR2 (UniProtKB)
Alt. Names/Synonyms: Apoptosis signal-regulating kinase 2; Ask2; M3K6; Map3k6; MAPKK; Mapkkk6; Mekk6; MGC159280; mitogen activated protein kinase kinase kinase 6; Mitogen-activated protein kinase kinase kinase 6; OTTMUSP00000011233
Gene Symbols: Map3k6
Molecular weight: 143,055 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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MEKK6

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene