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MEKK6
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: ASK subfamily; EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family |
| Chromosomal Location of mouse Ortholog: 4|4 D2.3 |
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Cellular Component:
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Molecular Function:
ATP binding; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cellular response to stress; phosphorylation; protein phosphorylation
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Reference #:
Q9WTR2
(UniProtKB)
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Alt. Names/Synonyms: Apoptosis signal-regulating kinase 2; Ask2; M3K6; Map3k6; MAPKK; Mapkkk6; Mekk6; MGC159280; mitogen activated protein kinase kinase kinase 6; Mitogen-activated protein kinase kinase kinase 6; OTTMUSP00000011233
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Gene Symbols: Map3k6
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Molecular weight:
143,055 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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