CDK10 Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK10 subfamily; CDK10 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  cell projection; ciliary basal body; cytoplasm; cytoskeleton; nucleus
Molecular Function:  ATP binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell projection organization; negative regulation of cilium assembly; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of MAPK cascade; protein phosphorylation; regulation of actin cytoskeleton organization
Reference #:  Q3UMM4 (UniProtKB)
Alt. Names/Synonyms: BC017131; Cdk10; Cell division protein kinase 10; cyclin dependent kinase 10; cyclin-dependent kinase (CDC2-like) 10; Cyclin-dependent kinase 10
Gene Symbols: Cdk10
Molecular weight: 40,961 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDK10

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene