DEM1
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. Belongs to the EXO5 family. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.11.- |
Chromosomal Location of mouse Ortholog: 4|4 D2.2 |
Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
4 iron, 4 sulfur cluster binding; DNA binding; exonuclease activity; hydrolase activity; iron-sulfur cluster binding; metal ion binding; nuclease activity; single-stranded DNA 5'-3' DNA exonuclease activity
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Biological Process:
DNA damage response; DNA repair; interstrand cross-link repair
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Reference #:
Q9CXP9
(UniProtKB)
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Alt. Names/Synonyms: 3110037I16Rik; AV297100; defects in morphology 1 homolog; defects in morphology 1 homolog (S. cerevisiae); Defects in morphology protein 1 homolog; Dem1; Exo V; EXO5; exonuclease 5; Exonuclease V; mExo5; OTTMUSP00000009237; probable exonuclease V
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Gene Symbols: Exo5
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Molecular weight:
41,624 Da
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Basal Isoelectric point:
5.17
Predict pI for various phosphorylation states
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