DEM1 Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. Belongs to the EXO5 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.11.-
Chromosomal Location of mouse Ortholog: 4|4 D2.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  4 iron, 4 sulfur cluster binding; DNA binding; exonuclease activity; hydrolase activity; iron-sulfur cluster binding; metal ion binding; nuclease activity; single-stranded DNA 5'-3' DNA exonuclease activity
Biological Process:  DNA damage response; DNA repair; interstrand cross-link repair
Reference #:  Q9CXP9 (UniProtKB)
Alt. Names/Synonyms: 3110037I16Rik; AV297100; defects in morphology 1 homolog; defects in morphology 1 homolog (S. cerevisiae); Defects in morphology protein 1 homolog; Dem1; Exo V; EXO5; exonuclease 5; Exonuclease V; mExo5; OTTMUSP00000009237; probable exonuclease V
Gene Symbols: Exo5
Molecular weight: 41,624 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
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DEM1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein