CENPT Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Belongs to the CENP-T/CNN1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 8|8 D3
Cellular Component:  chromosome; chromosome, centromeric region; kinetochore; nuclear body; nucleus
Molecular Function:  DNA binding; protein heterodimerization activity
Biological Process:  cell cycle; cell division; chromosome organization; chromosome segregation; kinetochore assembly; mitotic cell cycle
Reference #:  Q3TJM4 (UniProtKB)
Alt. Names/Synonyms: CENP-T; Cenpt; Centromere protein T; G630055P03Rik
Gene Symbols: Cenpt
Molecular weight: 56,242 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CENPT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein