GRK3 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Note: This description may include information from UniProtKB.
Protein type: AGC group; BARK subfamily; EC; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 5 F|5 55.29 cM
Cellular Component:  axon; dendrite terminus; dendritic shaft; dendritic spine; glutamatergic synapse; perinuclear region of cytoplasm; postsynaptic density; presynapse; sperm midpiece; Z disc
Molecular Function:  ATP binding; beta-adrenergic receptor kinase activity; D1 dopamine receptor binding; G protein-coupled receptor binding; G protein-coupled receptor kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  desensitization of G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; intracellular protein transport; phosphorylation; positive regulation of protein phosphorylation; protein phosphorylation; receptor internalization; rhodopsin metabolic process; signal transduction
Reference #:  Q3UYH7 (UniProtKB)
Alt. Names/Synonyms: 4833444A01Rik; Adrb; Adrbk; Adrbk-2; Adrbk2; adrenergic receptor kinase, beta 2; AI851927; ARBK2; AW551196; Bark; Bark-2; beta ARK2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; G protein-coupled receptor kinase 3; GRK3
Gene Symbols: Grk3
Molecular weight: 79,657 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein