IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 6 E3|6 52.82 cM
Cellular Component:  cytoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  cytokine-mediated signaling pathway; I-kappaB kinase/NF-kappaB signaling; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of DNA-binding transcription factor activity; negative regulation of NF-kappaB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; protein phosphorylation; regulation of apoptotic process; regulation of cytokine-mediated signaling pathway; response to interleukin-1; signal transduction
Reference #:  Q8CFA1 (UniProtKB)
Alt. Names/Synonyms: 6330415L08Rik; AI649099; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase 2c; Interleukin-1 receptor-associated kinase-like 2; IRA; IRAK-2; Irak2; MGC102586; mu-IRAK-2; OTTMUSP00000028052
Gene Symbols: Irak2
Molecular weight: 69,047 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene