ELG
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth. Belongs to the NCBP3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA-binding; Transcription factor |
Chromosomal Location of mouse Ortholog: 11|11 B4 |
Cellular Component:
cytoplasm; mRNA cap binding complex; nuclear cap binding complex; nuclear speck; nucleus
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Molecular Function:
mRNA binding; RNA 7-methylguanosine cap binding; RNA binding; RNA cap binding
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Biological Process:
7-methylguanosine mRNA capping; defense response to virus; mRNA export from nucleus; mRNA processing; mRNA transcription by RNA polymerase II; mRNA transport; snRNA export from nucleus
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Reference #:
Q8BZR9
(UniProtKB)
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Alt. Names/Synonyms: 1200014J11Rik; C130061O14Rik; C78393; ELG; ELG protein; NCBP3; nuclear cap binding subunit 3; Nuclear cap-binding protein subunit 3; OTTMUSP00000006413; Uncharacterized protein C17orf85 homolog
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Gene Symbols: Ncbp3
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Molecular weight:
70,043 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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