QSK Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3. Prevents HDAC4 translocation to the nucleus. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Expressed in chondrocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily
Chromosomal Location of mouse Ortholog: 9|9 A5.2
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity
Biological Process:  cartilage development involved in endochondral bone morphogenesis; endochondral ossification; intracellular signal transduction; limb morphogenesis; microtubule cytoskeleton organization; multicellular organism growth; phosphorylation; positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; protein phosphorylation; regulation of protein localization; skeletal system morphogenesis
Reference #:  Q6P4S6 (UniProtKB)
Alt. Names/Synonyms: 5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; Kiaa0999; MGC90906; MGC91236; mKIAA0999; Qsk; Salt-inducible kinase 3; Serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK family kinase 3; SIK-3; Sik3
Gene Symbols: Sik3
Molecular weight: 150,659 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene