SLC25A1
Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family |
Chromosomal Location of mouse Ortholog: 16 A3|16 11.11 cM |
Cellular Component:
membrane; mitochondrion
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Molecular Function:
antiporter activity; citrate secondary active transmembrane transporter activity; tricarboxylic acid transmembrane transporter activity
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Biological Process:
mitochondrial citrate transmembrane transport; transmembrane transport
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Reference #:
Q8JZU2
(UniProtKB)
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Alt. Names/Synonyms: 1300019P08Rik; 2610100G11Rik; AI194714; Citrate transport protein; Ctp; Dgs; Dgsj; DiGeorge syndrome gene j; MGC47055; Slc2; Slc20a3; Slc25a1; solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1; Solute carrier family 25 member 1; solute carrier family 25, member 1; Tricarboxylate carrier protein; tricarboxylate transport protein; Tricarboxylate transport protein, mitochondrial; TXTP
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Gene Symbols: Slc25a1
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Molecular weight:
33,931 Da
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Basal Isoelectric point:
9.91
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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