MAFA Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence. Belongs to the bZIP family. Maf subfamily. Expressed in the islets of Langerhans (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 15|15 D3
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  insulin secretion; nitric oxide mediated signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; response to glucose
Reference #:  Q8CF90 (UniProtKB)
Alt. Names/Synonyms: Mafa; Mafa homolog; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1; Transcription factor MafA; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian); V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
Gene Symbols: Mafa
Molecular weight: 37,576 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MAFA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene