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MON1A
Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 9|9 F1 |
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Cellular Component:
Mon1-Ccz1 complex
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Molecular Function:
guanyl-nucleotide exchange factor activity
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Biological Process:
establishment of localization in cell; intracellular iron ion homeostasis; protein secretion; protein targeting to vacuole; protein transport; vesicle-mediated transport
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Reference #:
Q6PDG8
(UniProtKB)
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Alt. Names/Synonyms: 2810468K17Rik; MON1 homolog A (yeast); MON1 homolog A, secretory traffciking associated; Mon1a; Vacuolar fusion protein MON1 homolog A
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Gene Symbols: Mon1a
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Molecular weight:
62,131 Da
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Basal Isoelectric point:
5.75
Predict pI for various phosphorylation states
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