PLEKHA7 Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 7|7 F1
Cellular Component:  cell junction; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; nucleus; zonula adherens
Molecular Function:  delta-catenin binding; protein binding
Biological Process:  cell-cell adhesion mediated by cadherin; epithelial cell-cell adhesion; zonula adherens maintenance
Reference #:  Q3UIL6 (UniProtKB)
Alt. Names/Synonyms: A430081P20Rik; AI414265; heart adaptor protein 1a; heart adaptor protein 1b; MGC90927; PH domain-containing family A member 7; PKHA7; pleckstrin homology domain containing, family A member 7; Pleckstrin homology domain-containing family A member 7; Plekha7
Gene Symbols: Plekha7
Molecular weight: 126,742 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein