QSOX2
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; EC 1.8.3.2; Membrane protein, integral; Oxidoreductase |
Chromosomal Location of mouse Ortholog: 2|2 A3 |
Cellular Component:
extracellular space; Golgi apparatus; membrane; nucleoplasm
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Molecular Function:
flavin-dependent sulfhydryl oxidase activity; oxidoreductase activity; protein disulfide isomerase activity; thiol oxidase activity
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Biological Process:
protein folding
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Reference #:
Q3TMX7
(UniProtKB)
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Alt. Names/Synonyms: BC030934; MGC31729; OTTMUSP00000013663; Qscn; Qscn6l1; QSO; Qsox2; quiescin Q6 sulfhydryl oxidase 2; quiescin Q6-like 1; Quiescin Q6-like protein 1; SOXN; Sulfhydryl oxidase 2
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Gene Symbols: Qsox2
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Molecular weight:
77,775 Da
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Basal Isoelectric point:
8.84
Predict pI for various phosphorylation states
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