QSOX2 Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Membrane protein, integral; Oxidoreductase
Chromosomal Location of mouse Ortholog: 2|2 A3
Cellular Component:  extracellular space; Golgi apparatus; membrane; nucleoplasm
Molecular Function:  flavin-dependent sulfhydryl oxidase activity; oxidoreductase activity; protein disulfide isomerase activity; thiol oxidase activity
Biological Process:  protein folding
Reference #:  Q3TMX7 (UniProtKB)
Alt. Names/Synonyms: BC030934; MGC31729; OTTMUSP00000013663; Qscn; Qscn6l1; QSO; Qsox2; quiescin Q6 sulfhydryl oxidase 2; quiescin Q6-like 1; Quiescin Q6-like protein 1; SOXN; Sulfhydryl oxidase 2
Gene Symbols: Qsox2
Molecular weight: 77,775 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene