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ADHFE1
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. Only expressed in adult liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.1.99.24; Mitochondrial; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 1|1 A2 |
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Cellular Component:
mitochondrion
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Molecular Function:
alcohol dehydrogenase (NAD+) activity; hydroxyacid-oxoacid transhydrogenase activity; metal ion binding; oxidoreductase activity
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Biological Process:
glutamate catabolic process via 2-oxoglutarate; lipid metabolic process
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Reference #:
Q8R0N6
(UniProtKB)
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Alt. Names/Synonyms: 6330565B14Rik; Adh8; ADHFe1; AI043035; alcohol dehydrogenase 8; Alcohol dehydrogenase iron-containing protein 1; alcohol dehydrogenase, iron containing, 1; Fe-containing alcohol dehydrogenase 1; HOT; Hydroxyacid-oxoacid transhydrogenase, mitochondrial; OTTMUSP00000025254
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Gene Symbols: Adhfe1
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Molecular weight:
49,937 Da
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Basal Isoelectric point:
7.25
Predict pI for various phosphorylation states
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