ADHFE1 Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. Only expressed in adult liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 1|1 A2
Cellular Component:  mitochondrion
Molecular Function:  alcohol dehydrogenase (NAD) activity; hydroxyacid-oxoacid transhydrogenase activity; metal ion binding; oxidoreductase activity
Biological Process:  glutamate catabolic process via 2-oxoglutarate; oxidation-reduction process
Reference #:  Q8R0N6 (UniProtKB)
Alt. Names/Synonyms: 6330565B14Rik; Adh8; ADHFe1; AI043035; alcohol dehydrogenase 8; Alcohol dehydrogenase iron-containing protein 1; alcohol dehydrogenase, iron containing, 1; Fe-containing alcohol dehydrogenase 1; HOT; Hydroxyacid-oxoacid transhydrogenase, mitochondrial; OTTMUSP00000025254
Gene Symbols: Adhfe1
Molecular weight: 49,937 Da
Basal Isoelectric point: 7.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene