HDAC1 a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p35.2-p35.1
Cellular Component:  chromatin; cytoplasm; cytosol; heterochromatin; histone deacetylase complex; neuronal cell body; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein-containing complex; Sin3 complex; transcription factor complex
Molecular Function:  activating transcription factor binding; core promoter sequence-specific DNA binding; deacetylase activity; DNA-binding transcription factor activity; E-box binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; Krueppel-associated box domain binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NF-kappaB binding; p53 binding; promoter-specific chromatin binding; protein binding; protein deacetylase activity; protein N-terminus binding; repressing transcription factor binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription factor binding; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  beta-catenin-TCF complex assembly; blood coagulation; chromatin organization; chromatin remodeling; circadian regulation of gene expression; embryonic digit morphogenesis; endoderm development; epidermal cell differentiation; eyelid development in camera-type eye; fungiform papilla formation; hair follicle placode formation; hippocampus development; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; methylation-dependent chromatin silencing; negative regulation by host of viral transcription; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron differentiation; odontogenesis of dentin-containing tooth; positive regulation of cell proliferation; positive regulation of oligodendrocyte differentiation; positive regulation of receptor biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein deacetylation; regulation of amyloid-beta clearance; regulation of endopeptidase activity; regulation of megakaryocyte differentiation; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II
Reference #:  Q13547 (UniProtKB)
Alt. Names/Synonyms: DKFZp686H12203; GON-10; HD1; HDAC1; Histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
Gene Symbols: HDAC1
Molecular weight: 55,103 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein