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CCDC132
Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Belongs to the syndetin family. Ubiquitous, with higher expression in brain and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 6|6 A1 |
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Cellular Component:
EARP complex; endosome; membrane; perinuclear region of cytoplasm; recycling endosome
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Molecular Function:
SNARE binding
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Biological Process:
endocytic recycling; protein transport; retrograde transport, endosome to Golgi
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Reference #:
Q8CI71
(UniProtKB)
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Alt. Names/Synonyms: 1700034M03Rik; 8430415E05Rik; Bcl2-like protein blm; BLM; C87205; CC132; Ccdc132; coiled-coil domain containing 132; Coiled-coil domain-containing protein 132; EARP/GARPII complex subunit VPS50; Kiaa1861; mKIAA1861; Syndetin; VPS50; VPS50 EARP/GARPII complex subunit
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Gene Symbols: Vps50
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Molecular weight:
111,174 Da
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Basal Isoelectric point:
5.76
Predict pI for various phosphorylation states
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