CCDC132 Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Belongs to the syndetin family. Ubiquitous, with higher expression in brain and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 6|6 A1
Cellular Component:  EARP complex; endosome; perinuclear region of cytoplasm; recycling endosome
Molecular Function:  SNARE binding
Biological Process:  endocytic recycling; protein transport; retrograde transport, endosome to Golgi
Reference #:  Q8CI71 (UniProtKB)
Alt. Names/Synonyms: 1700034M03Rik; 8430415E05Rik; Bcl2-like protein blm; BLM; C87205; CC132; Ccdc132; coiled-coil domain containing 132; Coiled-coil domain-containing protein 132; EARP/GARPII complex subunit VPS50; Kiaa1861; mKIAA1861; Syndetin; VPS50; VPS50 EARP/GARPII complex subunit
Gene Symbols: Ccdc132
Molecular weight: 111,174 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Select Structure to View Below

CCDC132

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene