DNAJC13 Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). {ECO:0000269|PubMed:18256511, ECO:0000269|PubMed:18307993, ECO:0000269|PubMed:24643499}. Interacts with FAM21C; mediates the association with the WASH complex (PubMed:24643499). {ECO:0000269|PubMed:24643499}.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 9|9 F1
Cellular Component:  cytosol; early endosome membrane; endosome membrane; intracellular membrane-bound organelle; WASH complex
Biological Process:  endosome organization and biogenesis; receptor-mediated endocytosis; regulation of early endosome to late endosome transport
Reference #:  G3X922 (UniProtKB)
Alt. Names/Synonyms: D030002L11Rik; DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ heat shock protein family (Hsp40) member C13; Dnajc13; Gm1124; j-domain containing protein, required for endocytosis; KIAA0678; receptor mediated endocytosis RME-8; RME-8; Rme8
Gene Symbols: Dnajc13
Molecular weight: 254,441 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Select Structure to View Below

DNAJC13

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein