MT-ATP8 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Belongs to the ATPase protein 8 family. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter
Chromosomal Location of human Ortholog: -
Cellular Component:  integral component of membrane; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Molecular Function:  proton transmembrane transporter activity; transmembrane transporter activity
Biological Process:  ATP biosynthetic process; cristae formation; mitochondrial ATP synthesis coupled proton transport
Reference #:  P03928 (UniProtKB)
Alt. Names/Synonyms: A6L; ATP synthase F0 subunit 8; ATP synthase protein 8; ATP8; ATPASE8; F-ATPase subunit 8; mitochondrially encoded ATP synthase 8; MT-ATP8; MTATP8
Gene Symbols: MT-ATP8
Molecular weight: 7,992 Da
Basal Isoelectric point: 9.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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