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CYFIP2
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Belongs to the CYFIP family. Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 11|11 B1.1 |
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Cellular Component:
cytoplasm; neuron projection; nucleus; perinuclear region of cytoplasm; SCAR complex; synapse
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Molecular Function:
protein binding; RNA 7-methylguanosine cap binding; small GTPase binding
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Biological Process:
activation of cysteine-type endopeptidase activity; apoptotic process; axon guidance; cell adhesion; cell morphogenesis; cell projection assembly; cell-cell adhesion; dendrite extension; neuron projection development; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of proteolysis; regulation of actin filament polymerization
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Reference #:
Q5SQX6
(UniProtKB)
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Alt. Names/Synonyms: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; Cyfip2; CYFP2; cytoplasmic FMR1 interacting protein 2; Cytoplasmic FMR1-interacting protein 2; Kiaa1168; mKIAA1168; OTTMUSP00000005638; p53-inducible protein 121; Pir; Pir121
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Gene Symbols: Cyfip2
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Molecular weight:
145,659 Da
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Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
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