YTHDC2 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293). Note: This description may include information from UniProtKB.
Protein type: EC; RNA-binding
Chromosomal Location of Human Ortholog: 18|18 B3
Cellular Component:  cytoplasm; endoplasmic reticulum; nucleus; ribonucleoprotein granule
Molecular Function:  3'-5' RNA helicase activity; ATP binding; ATP-dependent 3'-5' RNA helicase activity; helicase activity; hydrolase activity; N6-methyladenosine-containing RNA binding; nucleic acid binding; nucleotide binding; protein binding; RNA binding; RNA polymerase binding; RNA-dependent ATPase activity
Biological Process:  cell differentiation; germline cell cycle switching, mitotic to meiotic cell cycle; meiotic cell cycle; oocyte development; oogenesis; positive regulation by host of viral genome replication; response to interleukin-1; response to tumor necrosis factor; spermatid development; spermatogenesis
Reference #:  B2RR83 (UniProtKB)
Alt. Names/Synonyms: 3'-5' RNA helicase YTHDC2; 3010002F02Rik; BC037178; Keen to exit meiosis leaving testes under-populated protein; Ketu; mYTHDC2; Probable ATP-dependent RNA helicase YTHDC2; YTDC2; YTH domain containing 2; YTH domain-containing protein C2; Ythdc2
Gene Symbols: Ythdc2
Molecular weight: 161,092 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene