|
MAP2
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2q34 |
|
Cellular Component:
apical distal dendrite; axon hillock; axon initial segment; basal dendrite; cytoplasm; cytosol; dendrite; dendrite cytoplasm; dendritic branch; dendritic filopodium; dendritic growth cone; dendritic shaft; distal dendrite; main axon; microtubule; microtubule associated complex; neuron projection; neuronal cell body; primary dendrite; proximal dendrite; proximal neuron projection
|
|
Molecular Function:
calmodulin binding; dystroglycan binding; microtubule binding; protein binding; structural molecule activity; tau protein binding
|
|
Biological Process:
central nervous system neuron development; dendrite development; dendrite morphogenesis; microtubule cytoskeleton organization; negative regulation of axon extension; negative regulation of microtubule binding; negative regulation of microtubule polymerization; neuron projection development; positive regulation of anterograde dense core granule transport; positive regulation of anterograde synaptic vesicle transport; regulation of microtubule polymerization; regulation of organelle transport along microtubule; regulation of protein localization
|
|
Reference #:
P11137
(UniProtKB)
|
|
Alt. Names/Synonyms: DKFZp686I2148; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; microtubule associated protein 2; Microtubule-associated protein 2; MTAP2
|
|
Gene Symbols: MAP2
|
|
Molecular weight:
199,526 Da
|
|
Basal Isoelectric point:
4.82
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
