NOT1 represses ligand-dependent transcriptional activation by oestrogen receptor (ER) alpha and several RXR heterodimers. Interacts with the ligand-binding domain of estrogen receptor-alpha in a hormone-dependent fashion. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 8|8 D1
Cellular Component:  CCR4-NOT complex; CCR4-NOT core complex; cytoplasm; cytosol; nucleus; P-body
Molecular Function:  armadillo repeat domain binding; estrogen receptor binding; molecular adaptor activity; protein binding; protein domain specific binding; retinoic acid receptor binding
Biological Process:  gene silencing by miRNA; gene silencing by RNA; multicellular organism development; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of translation; positive regulation of cytoplasmic mRNA processing body assembly; positive regulation of mRNA catabolic process; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance; regulation of translation; trophectodermal cell differentiation
Reference #:  Q6ZQ08 (UniProtKB)
Alt. Names/Synonyms: 6030411K04Rik; AA815922; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex, subunit 1; Cnot1; D830048B13; Kiaa1007; MGC189870; MGC189936; MGC7843
Gene Symbols: Cnot1
Molecular weight: 266,808 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA