RBM16 Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of mouse Ortholog: 17|17 A1
Cellular Component:  cytoplasm; nuclear matrix; nucleoplasm; nucleus; spliceosomal complex
Molecular Function:  mRNA binding; nucleic acid binding; protein domain specific binding; RNA binding; RNA polymerase binding; RNA polymerase core enzyme binding; RNA polymerase II complex binding
Biological Process:  mRNA polyadenylation; mRNA processing; RNA splicing; termination of RNA polymerase II transcription; transcription by RNA polymerase II
Reference #:  Q6DID3 (UniProtKB)
Alt. Names/Synonyms: A630086M08Rik; A930036P18Rik; AA408306; AI447644; AI448652; AU015035; CTD-binding SR-like protein rA8; KIAA1116; mKIAA1116; MKIAA1116 protein; Protein SCAF8; putative RNA-binding protein 16; Rbm1; Rbm16; RNA binding motif protein 16; RNA-binding motif protein 16; SCAF8; SR-like CTD-associated factor 8; SR-related and CTD-associated factor 8; SR-related CTD-associated factor 8
Gene Symbols: Rbm16
Molecular weight: 139,572 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
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RBM16

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene