UBF Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  fibrillar center; nucleolus; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase I CORE element sequence-specific DNA binding; RNA polymerase I upstream control element sequence-specific DNA binding; scaffold protein binding
Biological Process:  positive regulation of transcription by RNA polymerase I; regulation of transcription by RNA polymerase I; regulation of transcription by RNA polymerase II; RNA polymerase I preinitiation complex assembly; termination of RNA polymerase I transcription; transcription by RNA polymerase I; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter
Disease: Neurodegeneration, Childhood-onset, With Brain Atrophy
Reference #:  P17480 (UniProtKB)
Alt. Names/Synonyms: 90-kDa nucleolus organizer region autoantigen; Autoantigen NOR-90; CONDBA; NOR-90; Nucleolar transcription factor 1; UBF; UBF-1; UBF1; UBF2; UBTF; upstream binding transcription factor; upstream binding transcription factor, RNA polymerase I; Upstream-binding factor 1
Gene Symbols: UBTF
Molecular weight: 89,406 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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Protein Structure Not Found.

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