DGKD May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. Belongs to the eukaryotic diacylglycerol kinase family. Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1|1 D
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; plasma membrane
Molecular Function:  diacylglycerol kinase activity; identical protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; protein homooligomerization; response to organic substance
Reference #:  E9PUQ8 (UniProtKB)
Alt. Names/Synonyms: AI841987; D330025K09; DAG kinase delta; Dgkd; dgkd-2; DGKdel; DGKdelta; Diacylglycerol kinase; Diacylglycerol kinase delta; diacylglycerol kinase, delta; KIAA0145; mKIAA0145
Gene Symbols: Dgkd
Molecular weight: 135,208 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
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DGKD

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein