ARID1B Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically. Widely expressed with high levels in heart, skeletal muscle and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17|17 A1
Cellular Component:  cytoplasm; cytosol; nBAF complex; nucleoplasm; nucleus; plasma membrane; SWI/SNF complex
Molecular Function:  DNA binding; protein binding
Biological Process:  chromatin organization; chromatin remodeling; dendritic cell dendrite assembly; dendritic spine development; nervous system development; neuron-neuron synaptic transmission
Reference #:  E9Q4N7 (UniProtKB)
Alt. Names/Synonyms: 8030481M12; 9330189K18Rik; AI836955; Ardi1b; Arid1b; AT rich interactive domain 1B (SWI-like); AT rich interactive domain 1B (Swi1 like); AT-rich interactive domain-containing protein 1B; B230217J03Rik; mKIAA1235
Gene Symbols: Arid1b
Molecular weight: 237,795 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein