SENP6 Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Belongs to the peptidase C48 family. Highly expressed in reproductive organs, such as testis, ovary and prostate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Sumo-specific protease
Chromosomal Location of mouse Ortholog: 9|9 E1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  cysteine-type peptidase activity; hydrolase activity; peptidase activity; SUMO-specific endopeptidase activity
Biological Process:  protein desumoylation; protein modification by small protein removal; proteolysis; regulation of kinetochore assembly; regulation of spindle assembly
Reference #:  Q6P7W0 (UniProtKB)
Alt. Names/Synonyms: 2810017C20Rik; E130319N12Rik; Kiaa0797; MGC38009; mKIAA0797; Senp6; Sentrin-specific protease 6; Sentrin/SUMO-specific protease SENP6; SUMO-1-specific protease 1; SUMO/sentrin specific peptidase 6; SUMO/sentrin specific protease 6; Susp1
Gene Symbols: Senp6
Molecular weight: 127,013 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene