FCHSD2 Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes. Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7|7 E2
Cellular Component:  cell junction; cell projection; cytoplasm; membrane; neuromuscular junction; plasma membrane; recycling endosome; stereocilium shaft
Molecular Function:  lipid binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding
Biological Process:  clathrin-dependent endocytosis; endocytosis; multi-organism membrane organization; neuromuscular synaptic transmission; positive regulation of actin filament polymerization; positive regulation of Arp2/3 complex-mediated actin nucleation; protein transport; regulation of actin filament polymerization
Reference #:  Q3USJ8 (UniProtKB)
Alt. Names/Synonyms: BC034086; F-BAR and double SH3 domains protein 2; FCH and double SH3 domains 2; FCH and double SH3 domains protein 2; Fchsd2; FCSD2; Kiaa0769; mKIAA0769; NWK1; Protein nervous wreck 1; R74866; SH3 multiple domains 3; SH3 multiple domains protein 3; Sh3md; Sh3md3
Gene Symbols: Fchsd2
Molecular weight: 84,282 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene