MLK2 Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in brain and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of mouse Ortholog: 7|7 A3
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; bHLH transcription factor binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity; transferase activity
Biological Process:  activation of JUN kinase activity; cell death; MAPK cascade; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription, DNA-templated; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of JUN kinase activity; protein phosphorylation; smoothened signaling pathway
Reference #:  Q66L42 (UniProtKB)
Alt. Names/Synonyms: BC028668; BC046514; M3K10; Map3k10; Mitogen-activated protein kinase kinase kinase 10; mixed lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 kinase; Mlk; Mlk2; MST; serine/threonine kinase
Gene Symbols: Map3k10
Molecular weight: 103,187 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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MLK2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein