RAP1GAP GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 4 D3|4 70.02 cM
Cellular Component:  axon; cytoplasm; cytosol; dendrite; early endosome; Golgi apparatus; membrane; neuronal cell body
Molecular Function:  GTPase activator activity; GTPase regulator activity; protein binding; protein homodimerization activity; small GTPase binding
Biological Process:  activation of GTPase activity; cell-cell adhesion; cellular response to glial cell derived neurotrophic factor; establishment of localization in cell; negative regulation of GTP binding; negative regulation of microvillus assembly; negative regulation of neuron differentiation; negative regulation of thyroid gland epithelial cell proliferation; phagocytosis; positive regulation of cell-cell adhesion; positive regulation of GTPase activity; positive regulation of phagocytosis; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
Reference #:  A2ALS5 (UniProtKB)
Alt. Names/Synonyms: 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; Gap; Kiaa0474; mKIAA0474; MKIAA0474 protein; Rap; Rap1 GTPase-activating protein; Rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1ga1; Rap1gap; Rap1GAP1; RPGP1
Gene Symbols: Rap1gap
Molecular weight: 73,433 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene