AARSL Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of mouse Ortholog: 17|17 B3
Cellular Component:  cytoplasm; mitochondrion
Molecular Function:  alanine-tRNA ligase activity; aminoacyl-tRNA editing activity; aminoacyl-tRNA ligase activity; ligase activity; metal ion binding; nucleic acid binding; nucleotide binding; RNA binding
Biological Process:  alanyl-tRNA aminoacylation; mitochondrial alanyl-tRNA aminoacylation; translation; tRNA aminoacylation
Reference #:  Q14CH7 (UniProtKB)
Alt. Names/Synonyms: Aars2; Aarsl; Alanine--tRNA ligase; Alanine--tRNA ligase, mitochondrial; Alanyl-tRNA synthetase; alanyl-tRNA synthetase 2, mitochondrial; alanyl-tRNA synthetase 2, mitochondrial (putative); alanyl-tRNA synthetase like; alanyl-tRNA synthetase, mitochondrial; Alanyl-tRNA synthetase-like; AlaRS; Gm89; Kiaa1270; MGC69820; Probable alanyl-tRNA synthetase, mitochondrial; SYAM
Gene Symbols: Aars2
Molecular weight: 106,783 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein