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AARSL
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. Note: This description may include information from UniProtKB.
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| Protein type: Aminoacyl-tRNA synthetase; EC 6.1.1.7; Ligase; Translation; Translation regulation |
| Chromosomal Location of mouse Ortholog: 17|17 B3 |
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Cellular Component:
cytoplasm; mitochondrion
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Molecular Function:
alanine-tRNA ligase activity; aminoacyl-tRNA editing activity; aminoacyl-tRNA ligase activity; ligase activity; metal ion binding; nucleic acid binding; nucleotide binding; RNA binding
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Biological Process:
alanyl-tRNA aminoacylation; mitochondrial alanyl-tRNA aminoacylation; translation; tRNA aminoacylation
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Reference #:
Q14CH7
(UniProtKB)
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Alt. Names/Synonyms: Aars2; Aarsl; Alanine--tRNA ligase; Alanine--tRNA ligase, mitochondrial; Alanyl-tRNA synthetase; alanyl-tRNA synthetase 2, mitochondrial; alanyl-tRNA synthetase 2, mitochondrial (putative); alanyl-tRNA synthetase like; alanyl-tRNA synthetase, mitochondrial; Alanyl-tRNA synthetase-like; AlaRS; Gm89; Kiaa1270; MGC69820; Probable alanyl-tRNA synthetase, mitochondrial; SYAM
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Gene Symbols: Aars2
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Molecular weight:
106,783 Da
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Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
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