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CYP3A5
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 |
| Chromosomal Location of Human Ortholog: 7q22.1 |
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Cellular Component:
endoplasmic reticulum membrane; intracellular membrane-bounded organelle
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Molecular Function:
aromatase activity; estrogen 16-alpha-hydroxylase activity; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding
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Biological Process:
alkaloid catabolic process; drug catabolic process; lipid hydroxylation; oxidative demethylation; steroid metabolic process; xenobiotic metabolic process
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Disease: Hypertension, Essential
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Reference #:
P20815
(UniProtKB)
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Alt. Names/Synonyms: aryl hydrocarbon hydroxylase; CP35; CP3A5; CYP3A5; CYPIIIA5; cytochrome P-450; Cytochrome P450 3A5; cytochrome P450 family 3 subfamily A member 5; Cytochrome P450 HLp2; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; Cytochrome P450-PCN3; DKFZp686L16231; flavoprotein-linked monooxygenase; microsomal monooxygenase; niphedipine oxidase; P450PCN3; PCN3; xenobiotic monooxygenase
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Gene Symbols: CYP3A5
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Molecular weight:
57,109 Da
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Basal Isoelectric point:
8.86
Predict pI for various phosphorylation states
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