FGR Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Mitochondrial; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of human Ortholog: 1p35.3
Cellular Component:  aggresome; cytosol; extracellular region; mitochondrial inner membrane; mitochondrial intermembrane space; plasma membrane; secretory granule lumen
Molecular Function:  ATP binding; Fc-gamma receptor I complex binding; immunoglobulin receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine kinase activity
Biological Process:  bone mineralization; defense response to Gram-positive bacterium; Fc-gamma receptor signaling pathway involved in phagocytosis; immune response-regulating cell surface receptor signaling pathway; innate immune response; integrin-mediated signaling pathway; neutrophil degranulation; peptidyl-tyrosine phosphorylation; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; protein autophosphorylation; protein phosphorylation; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; response to virus; skeletal system morphogenesis
Reference #:  P09769 (UniProtKB)
Alt. Names/Synonyms: c-fgr; c-fgr protooncogene; c-src-2 proto-oncogene; c-src2; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR; FGR proto-oncogene, Src family tyrosine kinase; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; p55-c-fgr protein; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; Tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Gene Symbols: FGR
Molecular weight: 59,479 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FGR

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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein